Reducing Pain of Lidocaine Injection

Completed · Phase 4

Conditions studied: Pain of Anesthesia at Breast Biopsy

In brief

The purpose of this study is to determine the benefit, if any, of buffering lidocaine (adding sodium bicarbonate) when used for local anesthesia prior to percutaneous breast needle core biopsies. The medicine doctors use to reduce the pain of breast biopsies, lidocaine, can cause pain for approximately 15 seconds until the numbing effect begins. It is possible that this pain is caused because lidocaine is acidic. Some physicians believe that reducing the acidity of lidocaine by mixing it with sodium bicarbonate will reduce the initial pain of injecting the lidocaine. Both approaches - injecting 1% lidocaine alone and injecting 1% lidocaine mixed with sodium bicarbonate - are used as routine standard of care by radiologists today. The purpose of this study is to determine if either approach is more comfortable for patients having breast procedures.

Key facts

Study ID

NCT02288364

Run by

Duke University

People needed

88

Starts

2014-12-01

Expected to finish

2015-08-01

Last updated by the study team

2016-04-15

Who can join

Age: 21 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 21 Years of age
• Any patient scheduled for a breast biopsy at Duke Breast Interventional Imaging

You may not qualify if…

• Less than 21 Years of age
• Allergic to Lidocaine or Sodium Bicarbonate
• Not mentally capable of consenting

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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