Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps

Stopped early · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Chronic Rhinosinusitis

In brief

The purpose of this randomized controlled double-blinded trial is to determine if the addition of an oral antifungal to typical post-operative medical therapy can prevent or reduce the incidence of recurrence of nasal polyps in fungal sensitive patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Key facts

Study ID

NCT02285283

Run by

The University of Texas Health Science Center, Houston

People needed

58

Starts

2014-11-01

Expected to finish

2019-05-15

Last updated by the study team

2020-10-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet criteria for diagnosis of CRS with nasal polyps undergoing medically indicated sinus surgery

You may not qualify if…

• cystic fibrosis
• aspirin exacerbated respiratory disease
• uncontrolled or unstable chronic diseases such as uncontrolled diabetes
• active or history of cancer
• HIV positive
• history of liver or kidney disease
• history of disease with effects on immune system
• pregnant
• allergy to triazole antifungals

Where it is running

• University of Texas Medical School at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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