[18F]ISO-1 Positron Emission Tomography (PET/CT) in Primary Breast Cancer

Running, not enrolling · Phase 1

Conditions studied: Breast Cancer, Breast Neoplasm

In brief

In this study, positron emission tomography (PET/CT) imaging will be used to evaluate sigma-2 (σ2) receptor activity in sites of primary breast cancer using the investigational radiotracer \[18F\]ISO-1.

Key facts

Study ID

NCT02284919

Run by

University of Pennsylvania

People needed

30

Starts

2015-03-11

Expected to finish

2026-11-01

Last updated by the study team

2026-01-09

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients, at least 18 years of age
• Known or suspected breast cancer with at least one breast lesion that is 1 cm or greater in size by standard imaging (e.g. mammography, ultrasound or breast MRI)
• Participants must be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures

You may not qualify if…

• Females who are pregnant at the time of screening will not be eligible for this study, urine or serum pregnancy test will be performed in women of child-bearing potential at the time of screening.
• Inability to tolerate imaging procedure in the opinion of an investigator or treating physician
• Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.
• Unwilling or unable to provide informed consent.

Where it is running

• University of Pennsylvania Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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