Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATE
Completed · Not applicable
Conditions studied: Respiratory Failure
In brief
Insertion of a breathing tube to enable treatment with mechanical ventilation (respirator) is often associated with complications, such as infection and lung injury. Leakage of secretions around the breathing tube (microaspiration) is a major factor leading to complications. The investigators propose that a standardized, enhanced oral suction protocol will be effective in reducing microaspiration and harms associated with mechanical ventilation. The investigators hypothesize that those randomized to the enhanced oral suction protocol will have less microaspiration and other ventilator-associated conditions than those in the usual care, standard suction group.
Key facts
- Study ID
- NCT02284178
- Run by
- University of Central Florida
- People needed
- 513
- Starts
- 2014-08-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2019-08-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or older
- orally intubated with endotracheal tube and treated with mechanical ventilation
- 24 hours or less since intubation
- expected to be intubated for at least 36 hours after enrollment
You may not qualify if…
- documented aspiration at time of intubation
- intubation to treat known aspiration
- treatment with rescue mechanical ventilation therapies (oscillator)
- re-intubation
- contraindications to receiving the intervention (e.g., oral injuries)
- history of lung or head/neck cancers that may produce amylase in the lungs
- history of disease that affects saliva production (e.g., Sjögren's syndrome)
- prisoners
Where it is running
- Orlando Regional Medical Center — Orlando, Florida, United States
Full record on ClinicalTrials.gov
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