Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

Withdrawn before enrolling · Phase 2

Conditions studied: Patients With "ASA 3" Designation

In brief

The purpose of this study is to compare the hemodynamic effects of a standardized induction of general anesthesia with either propofol or ketofol in patients with physical status classification ASA 3. The study will be a double blinded, randomized controlled trial (RCT) with two arms of treatment groups. One arm will consist of induction of general anesthesia using a mixture of 1.5mg/kg:0.75mg/kg Propofol/ketamine (ketofol) and the induction dose will be 1.5mg/kg of propofol and 0.75mg/kg of ketamine; the second arm will consist of induction of general anesthesia using propofol 2mg/kg. The primary outcome of the intervention will consist of hemodynamic changes during the first 30 minutes after induction of general anesthesia.

Key facts

Study ID

NCT02282891

Run by

Yale University

People needed

0

Starts

2015-01-01

Expected to finish

2016-08-01

Last updated by the study team

2016-12-15

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients age 18-80 scheduled for elective surgery
• Physical status ASA 3.

You may not qualify if…

• Patients with a physical status of ASA 1,2, 4 or 5,
• Prior adverse reaction to propofol, ketamine or both

Where it is running

• Yale New Haven Hospital — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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