The Effect of Dietary Salt Intake on Immune Function in Patients With Multiple Sclerosis

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The purpose of this work is to investigate the influence of dietary salt intake on immune function in multiple sclerosis (MS) subjects and healthy controls. This study primarily tests the hypothesis that higher dietary salt intake will be associated with a higher frequency of pathogenic Th17 cells and impaired function of protective regulatory T cells. If a relationship between dietary salt intake and immune function is observed, this study will also test: a) whether this relationship is unique to MS subjects or whether it is also present in healthy controls, and b) whether healthier immune function can be restored by restricting dietary salt intake.

Key facts

Study ID: NCT02282878
Run by: Yale University
People needed: 14
Starts: 2014-09-01
Expected to finish: 2019-12-08
Last updated by the study team: 2021-04-19

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Male or Female adult subjects
Ages 18-60, inclusive
diagnosis of CIS or MS by 2010 McDonald Criteria (in the case of MS subjects)
Naive to FDA- approved MS therapies such as glatiramer acetate, interferon-beta, natalizumab, fingolimod, tecfidera, or teriflunomide

You may not qualify if…

Secondary or primary progressive MS
Prior exposure to FDA-approved MS therapies or chemotherapies of any kind
Known history of autoimmune disease besides MS
Known history of renal disease, hypertension or congestive heart failure
Currently taking medications that could affect urine sodium excretion (e.g. diuretics or others that act on the renin-angiotensins-aldosterone system)

Where it is running

Yale MS Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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