Alterations in Muscle After Total Knee Arthroplasty

Completed · Not applicable

Conditions studied: Knee Osteoarthritis

In brief

The overall goals of this work are: 1) to elucidate alterations in gene expression and downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain quadriceps muscle atrophy after TKA and 2) understand the mechanisms responsible for improved maintenance of muscle strength with Neuromuscular Electrical Stimulation (NMES) utilization. Furthermore, this investigation seeks to expand previous findings regarding attenuation of strength and functional performance deficits with NMES application to better understand how altered gene expression influences muscle function.

Key facts

Study ID

NCT02281877

Run by

University of Colorado, Denver

People needed

20

Starts

2014-10-01

Expected to finish

2020-03-09

Last updated by the study team

2021-06-09

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 50 to 75 years of age
• Scheduled for unilateral TKA at University of Colorado Hospital
• Diagnosed with osteoarthritis
• Cognitive status that allows patients to consistently comprehend and repeat back directions regarding the details of the study

You may not qualify if…

• Neurological, vascular or cardiac problems that significantly limit function
• BMI > 35
• Testosterone supplementation
• Pregnancy
• Anticoagulant therapy

Where it is running

• Univeristy of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
• University of Colorado School of Medicine — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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