Transdermal Vagal Stimulation for POTS

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Postural Orthostatic Tachycardia Syndrome

In brief

Some patients experience high heart rates and symptoms of light-headedness, fatigue, headache during standing despite well maintained blood pressure. These patient are disabled and can't be in upright position for a longer time. The purpose of this study is to test whether electrical stimulation of a nerve through a skin of the ear may improve heart rate response and reduce disabling symptoms.

Key facts

Study ID

NCT02281097

Run by

Vanderbilt University

People needed

18

Starts

2013-06-01

Expected to finish

2026-12-31

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Non-smoking patients who qualify with the criteria of idiopathic postural tachycardia syndrome will be studied. The criteria are:
• an increase of heart rate of 30 beats/minute or an upright heart rate of >= 120 bpm, and
• chronic problems of symptoms during upright posture for at least 6 month.
• Subjects must also be able to safely withdrawn from medications that influence heart rate, blood pressure, and hormone levels that regulate blood pressure.
• The age limit is 18-75 years.

You may not qualify if…

• Patients that have other major medical problems, such as cancer or heart disease are excluded because the influence of that diagnosis on the symptoms is not known.
• Pregnancy.

Where it is running

• Autonomic Dysfunction Center, Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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