Using CBT to Probe Psychobiobehavioral Resilience to Post-trauma Psychopathology

Completed · Not applicable

Conditions studied: Anxiety, Depression

In brief

This randomized controlled trial uses a modularized cognitive behavioral resilience training (MCBRT) intervention to probe risk and resilience mechanisms linked to post-trauma psychopathology. Ninety participants with a history of interpersonal trauma during childhood or adolescence and mild to moderate distress will be randomized to MCBRT or a health education control condition. The primary aims of this proposal are to examine whether individuals who receive MCBRT demonstrate increases in psychological resilience, biological resilience, and extinction learning compared to those in the control group. This study will also explore associations between these psychobiobehavioral risk and resilience factors.

Key facts

Study ID

NCT02279290

Run by

Rush University Medical Center

People needed

58

Starts

2015-07-13

Expected to finish

2019-04-26

Last updated by the study team

2021-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• fluent in English
• history of childhood interpersonal trauma (e.g., sexual assault, physical assault, witnessing assault before age 18)
• mild to moderate distress indicated by a score of 10-20 on the depression scale, 8-14 on the anxiety scale, or 15-25 on the stress scale of the DASS-21.

You may not qualify if…

• severe distress indicated by a score >20 on the depression scale, >14 on the anxiety scale, or >25 on the stress scale of the DASS-21
• DSM-5 criterion A trauma in the past month
• color blindness based on self-report (because of inability to complete the fear conditioning task)
• auditory impairment based on audiometer screening (because of inability to complete the fear conditioning task)
• lifetime psychotic or bipolar disorder
• substance abuse or dependence within past 6 months
• concurrent psychotherapy initiated within 3 months of randomization
• ongoing psychotherapy of any duration directed toward treatment of trauma-related psychopathology (e.g., CBT)
• must be on a stable dose of psychotropic or adrenergically-active medications (e.g., beta blockers) for at least 6 weeks prior to eligibility screening
• mental retardation or significant cognitive impairment
• serious medical illness or instability for which hospitalization may be likely within the next year
• significant suicidal ideation indicated by "yes" on Columbia Suicide Severity Rating Scale item 4 (active suicidal ideation with some intent to act) or enacted suicidal behaviors within 6 months prior to eligibility
• current legal actions related to trauma.

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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