Tau Imaging in Professional Fighters
Completed · Phase 1
Conditions studied: Alzheimer's Disease
In brief
Subjects enrolled in the Professional Fighters Brain Health Study (PFBHS) will receive flortaucipir to explore its use as a biomarker for brain injury related to repetitive head trauma and to examine the relationship between clinical presentation and tau deposition.
Key facts
- Study ID
- NCT02278354
- Run by
- Avid Radiopharmaceuticals
- People needed
- 35
- Starts
- 2015-02-18
- Expected to finish
- 2017-02-03
- Last updated by the study team
- 2020-09-10
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- All Subjects
- Currently enrolled in the PFBHS protocol and have participated in a minimum of 10 professional fights
- Can tolerate Positron Emission Tomography (PET) scan procedures
- Have the ability to provide informed consent
- Subjects with cognitive impairment
- Have subjective cognitive complaints or objective decline or impairment as determined by the investigator
You may not qualify if…
- Have behavior dysfunction that is likely to interfere with imaging
- Are claustrophobic or otherwise unable to tolerate the imaging procedure
- Have current clinically significant cardiovascular disease or clinically significant abnormalities on screening electrocardiogram
- A history of additional risk factors for Torsades de Pointes (TdP) or are taking drugs that are known to cause QT-prolongation
- Have a current clinically significant infectious disease, endocrine or metabolic disease, pulmonary, renal or hepatic impairment, or cancer
- Have had a non-study related radiopharmaceutical imaging or treatment procedure within 7 days prior to the study imaging session
- Have current drug or alcohol dependence or alcohol dependence within the past 2 years
Where it is running
- Cleveland Clinic Lou Ruvo Center for Brain Health — Las Vegas, Nevada, United States
Full record on ClinicalTrials.gov
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