Screening for Age-Related Skeletal Muscle Dysfunction

Status unconfirmed

Conditions studied: Sarcopenia

In brief

This pilot study will aid the development of a sonographic screening method used to obtain proxy measures of LBM and estimates of muscle composition that relate to Intramuscular adipose tissue (IMAT), lipid metabolism, and insulin resistance. Typically, age-related muscle loss is not assessed in older adults until they began to show signs of trouble managing their own lives independently. In addition to the loss of independence that is typically seen with diminished muscle mass and function (sarcopenia), age-related changes in lean body mass can have negative effects on insulin sensitivity. The investigators central hypothesis is that the muscle characteristics derived from ultrasound (US) will be significantly associated with estimates of dual energy X-ray absorptiometry (DXA) LBM, CT scan measures of IMAT, estimates of insulin homeostasis, and serum levels of inflammatory cytokines.

Key facts

Study ID
NCT02277236
Run by
Washington D.C. Veterans Affairs Medical Center
People needed
30
Starts
2014-10-01
Expected to finish
2020-08-01
Last updated by the study team
2019-12-19

Who can join

Age: 45 and older, up to 85. Sex: male. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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