Oxytocin Effects on Food Motivation Pathways

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Overweight and Obesity

In brief

Oxytocin is a peptide hormone produced in the brain that regulates food intake. However, the mechanisms for this effect in humans is not yet clear. In this study, the investigators will therefore examine the effect of a single dose of intranasal oxytocin (compared to placebo) on levels of appetite-regulating hormones and functional magnetic resonance imaging activation of areas of the brain involved in food motivation.

Key facts

Study ID

NCT02276677

Run by

Massachusetts General Hospital

People needed

10

Starts

2014-10-01

Expected to finish

2015-05-01

Last updated by the study team

2019-04-08

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Age 18-45 years old
• BMI 25-40
• Regular breakfast eater (at least 4 times per week)
• Stable weight within the past three months

You may not qualify if…

• Psychiatric disease, use of psychotropic medications
• History of eating disorder
• History of excessive exercise within the last three months (having run more that 25 miles in any one week or having exercised more than ten hours in any one week)
• History of diabetes mellitus
• Active substance abuse
• Hematocrit lower than the normal range
• Gastrointestinal tract surgery (including gastrectomy, gastric bypass surgery, and small or large bowel resection)
• History of cardiovascular disease (such as hypertrophic cardiomyopathy, valvular heart disease, coronary heart disease, or coronary artery spasms)
• Untreated thyroid disease
• Tobacco use
• Cardiac pacemaker, surgical aneurysm clips, neurostimulator, implanted pumps, metal fragments in body/eyes, nitroglycerin patch, severe claustrophobia

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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