The Effect of Exercise on Neurorecovery Following Mild Traumatic Brain Injury
Completed · Not applicable
Conditions studied: Brain Concussion
In brief
The study is a "proof-of-principle" project to examine the safety and feasibility of implementing a 1-week aerobic exercise program in the post-acute phase after mild traumatic brain injury (mTBI). The study will define the extent to which the exercise program improves recovery from mTBI in terms of relevant functional outcomes (cognition, mood, and physical status) and biomarkers (peripheral brain-derived neurotrophic factor \[BDNF\] concentration).
Key facts
- Study ID
- NCT02276079
- Run by
- University of Florida
- People needed
- 39
- Starts
- 2015-02-17
- Expected to finish
- 2016-12-22
- Last updated by the study team
- 2018-12-04
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Meet criteria for mTBI as set forth by the American Congress of Rehabilitation Medicine
- mTBI was sustained 14-25 days before beginning the exercise intervention
You may not qualify if…
- comorbid orthopaedic injury that inhibits movement
- history of serious psychiatric disturbance with hospitalization,
- prior history of neurologic disease,
- current or past history of substance abuse disorder,
- diabetes
- previous history of moderate or severe head injury,
- neurological disorder unrelated to TBI (e.g., seizure disorder)
- physician recommendations against exercise
- non-English speakers
- Non-injured Group:
- Inclusion Criteria:
- Gainesville, Florida community member
- Exclusion Criteria:
- History of mTBI or other brain injury in the past year
- comorbid orthopaedic injury that inhibits movement
- history of serious psychiatric disturbance with hospitalization,
- prior history of neurologic disease,
- current or past history of substance abuse disorder,
- diabetes
- previous history of moderate or severe head injury,
- neurological disorder unrelated to TBI (e.g., seizure disorder)
- physician recommendations against exercise
- non-English speakers
Where it is running
- University of Florida Health Science Center — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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