Trajectory of Recovery in the Elderly

Completed · Not applicable

Conditions studied: Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction

In brief

The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who will be evaluated with a series of cognitive tests and a functional MRI. The participants will then be administered general anesthesia for two hours. The investigators will then assess the participants using state of the art tools to determine when participants return to their cognitive baseline.

Key facts

Study ID

NCT02275026

Run by

Icahn School of Medicine at Mount Sinai

People needed

104

Starts

2015-07-01

Expected to finish

2020-04-22

Last updated by the study team

2021-06-15

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 40-80 years old
• American Society of Anesthesiologists (ASA) Physical Status I or II (i.e. Individuals with minimal disease burden)
• Capable and willing to consent

You may not qualify if…

• Airway assessment as potentially difficult (Mallampati III or greater)
• Allergies or hypersensitivity to drug or class
• Chronic Inflammatory conditions such a lupus or system rheumatoid arthritis (arthritis limited to 1 or 2 joints will be acceptable)
• Patients with diabetes mellitus
• Patients with a recent illness (within the last 2 weeks)
• Patients with severe visual or auditory disorder/handicaps
• English illiteracy
• Pregnancy
• Participants not expected to be able to complete the postoperative tests
• History of malignant hyperthermia
• Nursing mothers
• Body Mass Index > 30
• Patients with significant metal implants in body
• Current use of cocaine or opiates
• Current smokers

Where it is running

• Icahn School of Medicine at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

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