Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery

Completed · Phase 4

Conditions studied: Post-operative Pain

In brief

Continuous femoral nerve blocks (CFNB) provide effective pain control to patients undergoing total knee replacement (TKR). However the resulting motor blockade can lead to decreased quadriceps muscle strength and delayed functional recovery.The purpose of this study is to compare the effect of Liposome Bupivacaine infiltration into the knee to CFNB on pain control and functional recovery

Key facts

Study ID

NCT02274870

Run by

Northwell Health

People needed

65

Starts

2014-11-01

Expected to finish

2017-01-01

Last updated by the study team

2018-06-14

Who can join

Age: 18 and older, up to 74. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA Status I-III
• Scheduled to undergo primary unilateral total knee arthroplasty

You may not qualify if…

• Patients who are pregnant or nursing
• Alcohol or narcotic dependence within the last 2 years
• Condition requiring regular use of analgesia that may confound post surgical assessments as determined by principle investigator
• BMI > 40kg/m2
• Contraindication to acetaminophen, morphine, oxycodone, ketorolac, epinephrine, or pathological conditions potentially aggravated by epinephrine
• Allergies to amide-type local anesthetics
• Any disease condition or lab result that could complicate a patients postoperative recovery
• History of hypotension
• Abnormal liver, renal or cardiac function
• Other physical, mental or medical conditions that, in the opinion of the investigator, make study participation inadvisable.

Where it is running

• Franklin — Valley Stream, New York, United States

Full record on ClinicalTrials.gov

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