rTMS for PTSD Comorbid With Major Depressive Disorder

Completed · Not applicable

Conditions studied: Posttraumatic Stress Disorder, Major Depressive Disorder, Transcranial Magnetic Stimulation, Repetitive

In brief

The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.

Key facts

Study ID

NCT02273063

Run by

Butler Hospital

People needed

40

Starts

2014-10-01

Expected to finish

2016-04-22

Last updated by the study team

2018-10-04

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• To ensure subjects can safely receive rTMS, eligible subjects must meet all established screening criteria for safety during MRI (magnetic resonance imaging), since MRI involves magnetic fields at similar intensity to those emitted from the rTMS treatment coil. These are conservative measures require a patient not having the following (unless MRI-safe): Cardiac pacemaker, implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord;
• Outpatients 18-70 years of age (inclusive)
• Meet DSM-IV criteria for MDD (recurrent or single episode chronic) and PTSD (acute or chronic) at the time of the screening and baseline visits;
• Have a baseline score of "Moderately Ill" or worse on both the CGI-S and the PGI-S.
• Have failed at least one antidepressant medication trial as part of definitive and adequate treatment in the current episode, OR have demonstrated intolerance to at least one antidepressant medication as part of attempted treatment in the current episode of illness (i.e., meet FDA labeling requirements for administration of rTMS for depression);
• Be on a stable psychotropic regimen for at least six weeks (42 days) prior to screening, or no psychotropic medication at all, and be willing to maintain the current regimen and dosing for the duration of the study (unless medical necessary to make changes with notification of research staff);
• If female and of child bearing potential, agree to use an acceptable method of birth control for the duration of the study treatment period
• Be willing and able to comply with all study related procedures and visits,
• Be capable of independently reading and understanding patient information materials and giving written informed consent.

You may not qualify if…

• Are pregnant or lactating or planning to become pregnant within the next three months.
• Have a lifetime history of loss of consciousness due to head injury for greater than 10 minutes, or any lifetime history of loss of consciousness due to a head injury with documented evidence of brain injury (including brain atrophy).
• Current (or past if appropriate) significant neurological disorder, or lifetime history of a) seizure disorder b) primary or secondary CNS tumors c) stroke or d) cerebral aneurysm;
• Current Axis 1 primary psychotic disorder, or bipolar I disorder, current alcohol and/or substance dependence or abuse within the past 1 month;
• Past treatment with TMS therapy
• Have active suicidal intent or plan as detected on screening assessments, or in the Investigator's opinion, is likely to attempt suicide within the next six months.
• Demonstrate the presence of any other condition or circumstance that, in the opinion of the investigator, has the potential to prevent study completion and/or to have a confounding effect on outcome assessments.

Where it is running

• Butler Hospital — Providence, Rhode Island, United States
• Providence VA Medical Center — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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