Prehospital Resuscitation On Helicopter Study

Completed

Conditions studied: Traumatic Injuries

In brief

The Prehospital Resuscitation On Helicopter Study (PROHS) is a pragmatic, multicenter, prospective observational study of air ambulance-based prehospital resuscitation regimens currently utilized at the participating sites. Patients will be enrolled at participating sites that currently have blood products available on air ambulances and other sites that do not. This study will not change the current prehospital standard of care for resuscitation. The primary outcome will be in-hospital mortality and the primary unit of analysis will be the patient. Other outcomes of interest will include time to hemostasis, hospital length-of-stay, number of ventilator-free and ICU-free days, incidence of major surgical procedures, complications (transfusion-related acute lung injury \[TRALI\], acute kidney injury \[AKI\], multiple organ failure \[MOF\], acute respiratory distress syndrome \[ARDS\], sepsis, intra-abdominal complications, thromboembolic complications, compartment syndromes), lifesaving interventions, the amount and type of blood products and concentrates transfused (including prehospital), wastage of prehospital blood products and concentrates, use of external and internal hemostatic devices, and functional status at discharge/discharge destination.

Key facts

Study ID

NCT02272465

Run by

The University of Texas Health Science Center, Houston

People needed

1049

Starts

2015-01-01

Expected to finish

2015-12-01

Last updated by the study team

2015-12-08

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Criteria for "at risk" population
• Patients with traumatic injuries received directly from the scene via air ambulance service (did not receive a lifesaving intervention at an outside hospital or healthcare facility)
• Estimated age of 15 or older or greater than/equal to a weight of 50 kg, if age unknown Criteria for "highest risk" population
• Meet at least one of the following during prehospital care: HR >120 bpm, SBP ≤90 mmHg, penetrating truncal injury, tourniquet application, pelvic binder application or intubation.
• Received blood products during transport (for those facilities with blood product availability)

You may not qualify if…

• Prisoners (defined as those received directly from a correctional facility.

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• University of Arizona — Tucson, Arizona, United States
• University of Southern California, Los Angeles — Los Angeles, California, United States
• University of Maryland School of Medicine — Baltimore, Maryland, United States
• Mayo Medical Center — Rochester, Minnesota, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Memorial Hermann Hospital - Texas Medical Center — Houston, Texas, United States
• University of Washington- Harborview Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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