Image Guided Radiotherapy (IGRT) for Prone Partial Breast Irradiation

Completed · Not applicable

Conditions studied: Breast Cancer

In brief

Partial breast irradiation (PBI) is becoming a new paradigm for breast cancer radiation.\[1\] No type I or II evidence is currently available to demonstrate equivalence to standard whole breast radiotherapy, and a prospective randomized trial jointly sponsored by NSABP and RTOG (NSABP B-39 and RTOG 0413) is currently accruing patients, comparing whole breast radiotherapy to PBI, either by brachytherapy or external beam techniques (EB). Until the results of this or similar trials are available, PBI remains a research domain, and it should be offered to patients only in the context of a clinical experimental protocol.

Key facts

Study ID

NCT02272400

Run by

NYU Langone Health

People needed

310

Starts

2007-08-07

Expected to finish

2014-10-29

Last updated by the study team

2021-01-14

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Post-menopausal women defined as either:
• at least 2 years without menstrual period or
• patients older than 50 with serological evidence of post-menopausal status or
• hysterectomized patients of any age with FSH confirmation of post-menopausal status
• pT1 breast cancer, excised with negative margins
• pN0 or sentinel node negative or N0 clinically if the tumor is < 1 cm in size

You may not qualify if…

• Previous radiation therapy to the ipsilateral breast
• Presence of a proportion of DCIS in the core biopsy specimen which is compatible with extensive intraductal component (EIC)

Where it is running

• Laura and Isaac Perlmutter Cancer Center at NYU — New York, New York, United States

Full record on ClinicalTrials.gov

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