Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Recruiting now · Phase 1/Phase 2

Conditions studied: Respiratory Disorders

In brief

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Key facts

Study ID

NCT02272049

Run by

Children's Hospital Medical Center, Cincinnati

People needed

300

Starts

2014-12-01

Expected to finish

2029-08-31

Last updated by the study team

2026-02-17

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 6 and up
• Participant must be able to hold breath for up to 16 seconds

You may not qualify if…

• History of heart defect
• Pregnancy or positive pregnancy test
• History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
• Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
• Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
• Participant is claustrophobic and unable to tolerate the imaging.
• Standard MRI exclusions (metal, implants)

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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