Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit
Completed
Conditions studied: Critical Illness, Sarcopenia, Muscle Wasting
In brief
The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a longer surgical intensive care unit and hospital length of stay, less ventilator-free days and a higher likelihood of an adverse discharge disposition. Our secondary aim is to identify muscle-size derived variables that can be used to predict frailty. We hypothesize that a low skeletal muscle mass measured by ultrasound can be used to quantify frailty, and to also predict the outcome of SICU patients, expressed as longer stay in the surgical intensive care unit and longer stay in the hospital, less ventilator-free days and a higher likelihood of an adverse discharge disposition. Our third aim is to examine potential triggers of muscle wasting in critically ill patients. Muscle wasting will be assessed by repetitive ultrasound measurements of muscle mass. We hypothesize that a significant decrease in skeletal muscle mass predicts longer stay at the surgical intensive care unit and longer hospital length of stay, less ventilator-free days and adverse discharge disposition.
Key facts
- Study ID
- NCT02270502
- Run by
- Massachusetts General Hospital
- People needed
- 111
- Starts
- 2014-05-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-03-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients admitted to the SICU (within 72 hours of admission)
- Age over 18 years
- Stay on the SICU for at least 24 hours
You may not qualify if…
- Ongoing discussions about goals of care
- Motor component of Glasgow Coma Scale <5
- Unstable fractures
- Preexisting paralysis
- Pregnancy
- Absence of both lower limbs
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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