The Impact of Artichoke Leaf Extract on Blood Cholesterol: Primary Study

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Lipid Metabolism Disorders

In brief

Pycrinil® is a purified extract of the artichoke leaf. Artichoke leaf extract (ALE) has some clinical trial data suggesting benefit in the treatment of cholesterol disorders in several countries, but this effect has not been studied in a U.S. population. The investigators will give ALE or a placebo to overweight men and women with low "good" cholesterol to see if ALE increases their good cholesterol. The investigators will also make sure that ALE is safe.

Key facts

Study ID

NCT02270164

Run by

University of Mississippi Medical Center

People needed

0

Starts

2014-10-01

Expected to finish

2016-02-01

Last updated by the study team

2016-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ≥18 years of age
• HDL cholesterol <40 mg/dL in men or <50 mg/dL in women
• BMI ≥25 kg/m2.

You may not qualify if…

• Patient on statins
• Triglycerides >400 mg/dL
• Low density lipoprotein (LDL) >190 mg/dL
• Significant hepatic disease (i.e., documented diagnosis of hepatic cancer, hepatitis, or cirrhosis)
• Significant renal disease (i.e., most recent glomerular filtration rate <30 mL/min/1.73 m2)
• Significant gastrointestinal tract disease (documented diagnosis of malabsorption disorder, GI cancer, or uncontrolled inflammatory bowel disease)
• History of transplant
• Women of reproductive potential not receiving birth control
• Pregnant/nursing women

Where it is running

• University of Mississippi Medical Center — Jackson, Mississippi, United States

Full record on ClinicalTrials.gov

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