Quantitative MRI in Assessing Disease in Patients With Brain Tumors
Stopped early · Not applicable
Conditions studied: Tumors Metastatic to Brain, Unspecified Adult Solid Tumor, Protocol Specific
In brief
This pilot clinical trial studies quantitative magnetic resonance imaging (MRI) at 3 Tesla in assessing disease in patients with tumors that have spread to the brain (brain metastases). In addition to routine care brain imaging of the brain, this study will include advanced multiparametric MRI sequences to measure vascular, cellular, and molecular properties of the tumor. Performing extra scans during MRI provides more information about the metastases and may better predict treatment response.
Key facts
- Study ID
- NCT02269111
- Run by
- Vanderbilt-Ingram Cancer Center
- People needed
- 10
- Starts
- 2015-04-01
- Expected to finish
- 2018-05-01
- Last updated by the study team
- 2018-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients must sign an Institutional Review Board (IRB)-approved informed consent document
- Patients must have been diagnosed with one of the following:
- Primary brain tumor (glioma, GBM etc); or
- Up to 10 brain metastases
- Patients must have been diagnosed with 1-4 brain metastases
- At least one of the brain metastases must measure 5 mm (or more) in short axis diameter in the axial plane
- Patients must be scheduled to undergo standard brain cancer interventions:
- Chemotherapy or targeted antiangiogenic therapy, in the case of primary brain tumor; or
- Stereotaxic radiotherapy (SRS) or whole brain radiotherapy (WBRT), in the case of brain metastases.
- Patients must be scheduled to receive a 3-Tesla (3T) MRI exam as part of their standard of care (this exam will be modified to also include pulse sequences with are for research only)
You may not qualify if…
- Patients who have received previous treatment (chemotherapy or radiotherapy) for any brain tumor (primary or metastatic).
- Patients who are scheduled to receive a 1.5T MRI exam
- Patients incapable of giving informed written consent, due to mental disability, altered mental status, confusion, cognitive impairment, or psychiatric disorders.
- Patients scoring 14.5 or lower on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC) questionnaire will not be allowed on the study
Where it is running
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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