Single Embryo TrAnsfeR of Euploid Embryo

Completed · Not applicable

Conditions studied: Infertility, Aneuploidy

In brief

The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a randomized controlled trial (RCT). All embryos will be vitrified and a single embryo transfer (SET) will be performed with either screened or unscreened embryos depending on randomization.

Key facts

Study ID

NCT02268786

Run by

Illumina, Inc.

People needed

661

Starts

2014-09-01

Expected to finish

2016-12-31

Last updated by the study team

2020-05-13

Who can join

Age: 25 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patient undergoing IVF
• At least 2 blastocysts suitable for biopsy on day 5 or 6 of embryo development

You may not qualify if…

• History of more than two prior implantation failure following IVF
• History of more than one miscarriage of viable pregnancy
• One or both partners known to be carrier(s) of a chromosomal abnormality
• Known genetic carrier couple and/or one or both partners carrier of a known autosomal dominant disorder
• Any other non-study related preimplantation genetic testing
• Use of donor oocytes
• Use of gestational carrier (surrogate or donor egg recipient).
• Severe oligospermia (<1,000,000 sperm/ml); Surgical Sperm Retrieval for reasons other than post-vasectomy and CAVD
• Low ovarian reserve with (FSH) >10 IU/L on day 2-4 of a prior menstrual cycle and/or (AMH) <7 pmol/L (or <1 ng/ml)
• Gender selection cycles
• Concurrent participation in another clinical trial

Where it is running

• Fertility Treatment Center — Tempe, Arizona, United States
• HRC Fertility — Encino, California, United States
• Acacio Fertility Clinic — Laguna Niguel, California, United States
• HRC Fertility Pasadena — Pasadena, California, United States
• Fertility Specialists Medical Group — San Diego, California, United States
• Reproductive Science Center of San Francisco Bay Area — San Ramon, California, United States
• Colorado Center for Reproductive Medicine (CCRM) — Lonetree, Colorado, United States
• Reproductive Associates of Delaware — Newark, Delaware, United States
• CRM Orlando — Orlando, Florida, United States
• Georgia Reproductive Specialists — Atlanta, Georgia, United States
• Fertility Institute of Hawaii — Honolulu, Hawaii, United States
• Fertility Center of Illinois, Highland Park — Highland Park, Illinois, United States
• The Advanced IVF Institute — Naperville, Illinois, United States
• IVF New England — Lexington, Massachusetts, United States
• IVF Michigan — Bloomfield Hills, Michigan, United States
• Genesis Genetics (USA) - Genetics Laboratory — Plymouth, Michigan, United States
• Reproductive Science Center of New Jersey — Eatontown, New Jersey, United States
• Reprogenetics (USA) - Genetics Laboratory — Livingston, New Jersey, United States
• IRMS at St. Barnabas — Livingston, New Jersey, United States
• Main Line Fertility — Bryn Mawr, Pennsylvania, United States
• Texas Fertility Center — Austin, Texas, United States
• Dallas Fertility Center — Dallas, Texas, United States
• Dallas IVF — Frisco, Texas, United States
• Houston Fertility Institute — Houston, Texas, United States
• CORM Houston — Webster, Texas, United States

Full record on ClinicalTrials.gov

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