Exercise Targeting Cognitive Impairment in Parkinson's Disease

Status unconfirmed · Not applicable

Conditions studied: Parkinson's Disease

In brief

The aim of this application is to compare and elucidate the effects of skill-based versus aerobic exercise versus control on mild cognitive impairment (MCI) of the executive function (EF) subtype in Parkinson's disease (PD); we hypothesize that skill-based exercise will result in the greatest improvement in EF and lead to modification of underlying neural substrates.

Key facts

Study ID

NCT02267785

Run by

University of Southern California

People needed

25

Starts

2014-10-01

Expected to finish

2019-12-01

Last updated by the study team

2019-05-31

Who can join

Age: 30 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• willing and able to provide informed consent
• confirmed diagnosis of idiopathic PD based on the United Kingdom Brain Bank criteria
• Mild cognitive impairment (Level II criteria Movement Disorder Task Force)
• medically eligible for MRI imaging
• able to provide a written medical clearance from their primary physician to participate in exercise
• stable PD medications for 3 months

You may not qualify if…

• a Hoehn \& Yahr staging greater than 2.5 at screening
• severe cardiac disease (New York Heart Association classification IIIV)
• history of an abnormal stress test
• clinically significant medical or psychiatric illness
• electrically, magnetically, or mechanically activated implant (such as cardiac pacemakers or intracerebral vascular clip)
• metal in any part of the body including metal injury to the eye
• past history of brain lesions (such as stroke)
• seizures or unexplained spells of loss of consciousness
• family history of epilepsy
• physical therapy within 6 months of the study
• symptomatic orthostatic hypotension at the screening visit
• orthopedic and other movement-influencing diseases such as arthritis or total hip joint replacement
• requirement for central nervous system active therapies (e.g. hypnotics, antidepressants, anxiolytics)
• moderate or severe depression or apathy using the Geriatric depression scale and Apathy scale
• taking anticholinesterase inhibitors
• taking anticholinergic medication
• PD dementia
• Colorblindness

Where it is running

• University of Southern California — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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