Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
Status unconfirmed
Conditions studied: Cardiovascular Disease, Atherosclerosis
In brief
Cardiovascular disease (CVD) remains the leading cause of death in the United States, and improved CVD risk assessment is needed for personalized medicine. Atherosclerosis measures including plaque volume and adverse plaque features have prognostic value. Novel techniques have been developed for assessing carotid, coronary, and femoral atherosclerosis using magnetic resonance imaging (MRI) methods that are rapid and reproducible, have improved spatial resolution, and do not require contrast media, making atherosclerosis assessment in multiple vascular beds feasible during a single MRI session. This pilot research will provide preliminary data to develop an innovative global atherosclerosis measure including carotid, coronary, and femoral vascular beds, for assessing cardiovascular risk and for monitoring atherosclerosis response to therapy. 20 participants will be recruited in one year.
Key facts
- Study ID
- NCT02265250
- Run by
- Cedars-Sinai Medical Center
- People needed
- 20
- Starts
- 2014-09-01
- Expected to finish
- 2024-10-01
- Last updated by the study team
- 2020-08-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women with evidence of coronary atherosclerosis based on a recent CACS 10-1000 or an invasive or CT coronary angiogram (within 6 weeks of recruitment)
- No planned revascularization procedures
You may not qualify if…
- Contraindications to MRI
- Pregnant and lactating women
- Body mass index (BMI)>40
- Active smoking
- Resting heart rate>75 beats per minute
- Arrhythmia
- Prior carotid/coronary/peripheral revascularization
- Life expectancy <5 years
- Allergy to animal dander
- Severe asthma
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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