Relationship of Pulmonary Contusion to Pulmonary Inflammation and Incidence of Acute Respiratory Distress Syndrome
Completed
Conditions studied: Pulmonary Contusion, Respiratory Failure, ARDS
In brief
Pulmonary contusion (PC) is a significant problem after blunt trauma that may often lead to acute respiratory distress syndrome (ARDS) and in some patients, death. Although the pathophysiology is incompletely understood, it is clear that there is a biochemical process involving changes in the inflammatory milieu after contusion which occurs in addition to simple direct mechanical injury to the lung. The relationship of severity of contusion on imaging, disturbances in the inflammatory phenotype, and outcome is unknown. This is a prospective, observational study which will evaluate the size and severity of contusion as measured on chest computed tomography (CT). Inflammatory mediators will be measured in the bronchoalveolar lavage (BAL) and in the serum of patients with pulmonary contusion to define the inflammatory nature of the post-contusion lung. The degree of abnormality within the inflammatory parameters will be correlated with lung contusion size and subsequent patient outcomes. These data will be compared to other patient groups: 1) Trauma patients without chest injury who are mechanically ventilated; 2) Uninjured patients undergoing elective surgical procedures that will require intubation and mechanical ventilation; 3) Patients in the Medical ICU who are mechanically ventilated with acute respiratory failure. The hypothesis tested within this study is resolution of lung injury is dependent upon the presence of Tregs in the alveolar space.
Key facts
- Study ID
- NCT02265198
- Run by
- Wake Forest University Health Sciences
- People needed
- 10
- Starts
- 2014-09-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2017-11-06
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 15 years old
- Chest trauma patients
- Medical ICU patients with respiratory failure
- Elective surgery patients
- Trauma or surgical ICU patients on ventilators without chest trauma/pulmonary contusion
You may not qualify if…
- Age 15 years and younger
- Pregnant women
- Subjects with multiple myeloma, pheochromocytoma, homozygous sickle cell disease, or thyroid disorders
- Traumatic brain injury requiring intracranial pressure monitoring
- Moribund status
Where it is running
- Wake Forest Baptist Health — Winston-Salem, North Carolina, United States
Full record on ClinicalTrials.gov
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