Challenging the Inflammatory Response System in Insomnia Disorder
Completed
Conditions studied: Insomnia
In brief
The main purpose of this study is to understand how insomnia (compared to good sleep) may affect the response of the body to a repeated physiological challenge, such as inserting the hand in ice-cold water for several times in a row. In particular, the investigators are interested in the response of markers that can be associated with stress, such as blood pressure and stress hormones.
Key facts
- Study ID
- NCT02261597
- Run by
- Beth Israel Deaconess Medical Center
- People needed
- 44
- Starts
- 2015-01-01
- Expected to finish
- 2018-03-01
- Last updated by the study team
- 2019-07-22
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Women and men between the ages 18-55 years
- Blood chemistry in the normal range
- BMI less than or equal to 35
- Specific to insomnia group:
- Diagnosis of insomnia disorder based on DSM-V criteria
- Specific for control group:
- Good quality and quantity sleep
You may not qualify if…
- Active infection/disease.
- History of neurological, chronic pain, immune, cardiovascular, liver/kidney, or metabolic disorder
- History of psychiatric disorders within the last 6 months prior to study start
- Sleep disorders other than insomnia
- Reynaud's disease
- Psychotropic, sleep, or any other medications or herbs interfering with the inflammatory, autonomic, or HPA system in the last 2 weeks prior to study start, except oral contraceptives
- In psychotherapy or any other behavioral interventions at study start
- Donation of blood or platelets within 3 months of hospital visits
- Pregnant/nursing.
- Substance abuse.
Where it is running
- BIDMC — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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