A Phase 1 Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Solid Tumors
Completed · Phase 1
Conditions studied: Advanced Solid Tumors
In brief
This is a multicenter, open-label, dose-exploration and dose-expansion study to evaluate the safety, tolerability, antitumor activity, PK and immunogenicity of MEDI4736 in combination with tremelimumab in subjects with select advanced solid tumors.
Key facts
- Study ID
- NCT02261220
- Run by
- MedImmune LLC
- People needed
- 380
- Starts
- 2014-10-13
- Expected to finish
- 2020-01-27
- Last updated by the study team
- 2020-03-06
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female subjects
- 18 years and older
- Histologic confirmation of advanced solid tumors
- Subjects must have recurrent/metastatic disease and may have been previously treated in the recurrent/metastatic setting.
You may not qualify if…
- Any concurrent chemotherapy, immune-mediated therapy or biologic or hormonal therapy for cancer treatment
- Active or prior documented autoimmune disease within the past 2 years
- Current or prior use of immunosuppressive medication within 14 days with some exceptions.
Where it is running
- Research Site — Duarte, California, United States
- Research Site — La Jolla, California, United States
- Research Site — Los Angeles, California, United States
- Research Site — Los Angeles, California, United States
- Research Site — Whittier, California, United States
- Research Site — Aurora, Colorado, United States
- Research Site — New Haven, Connecticut, United States
- Research Site — Miami Beach, Florida, United States
- Research Site — Tampa, Florida, United States
- Research Site — Chicago, Illinois, United States
- Research Site — Chicago, Illinois, United States
- Research Site — Iowa City, Iowa, United States
- Research Site — Louisville, Kentucky, United States
- Research Site — Ann Arbor, Michigan, United States
- Research Site — New York, New York, United States
- Research Site — New York, New York, United States
- Research Site — The Bronx, New York, United States
- Research Site — Cincinnati, Ohio, United States
- Research Site — Cleveland, Ohio, United States
- Research Site — Portland, Oregon, United States
- Research Site — Portland, Oregon, United States
- Research Site — Philadelphia, Pennsylvania, United States
- Research Site — Pittsburgh, Pennsylvania, United States
- Research Site — Greenville, South Carolina, United States
- Research Site — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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