Neuromuscular Blockade for Post-Cardiac Arrest Care

Completed · Phase 2

Conditions studied: Cardiac Arrest

In brief

The main purpose of this study is to evaluate if neuromuscular blockade improves lactate clearance (and preliminary secondary clinical outcome measures) as compared to usual care in post-cardiac arrest patients undergoing targeted temperature management.

Key facts

Study ID

NCT02260258

Run by

Beth Israel Deaconess Medical Center

People needed

83

Starts

2014-10-01

Expected to finish

2019-05-29

Last updated by the study team

2021-01-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (≥ 18 years)
• Cardiac arrest with sustained return of spontaneous circulation (ROSC)
• Comatose (i.e., not following commands) following ROSC
• Undergoing targeted temperature management (TTM)
• Time of enrollment ≤ 6 hours from initiation of targeted temperature management
• Serum Lactate ≥2

You may not qualify if…

• Pre-existing dementia, severe brain injury, or dependence on others for activities of daily living (i.e. a modified Rankin scale (mRS) score of 4 or higher)
• Traumatic etiology of the cardiac arrest
• Protected population (pregnant, prisoner)

Where it is running

• Michael Kurz — Birmingham, Alabama, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Robert Swor — Royal Oak, Michigan, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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