A Study of Carboplatin, Pemetrexed Plus Placebo vs Carboplatin, Pemetrexed Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With Non-Squamous Non-Small Cell Lung Cancer
Completed · Phase 2 · Has a placebo group
Conditions studied: Nonsquamous Nonsmall Cell Neoplasm of Lung
In brief
A randomized, double-blind, 3-arm (1:1:1) study in subjects with first-line Stage IV non-squamous NSCLC. The purpose is to test the efficacy and safety of demcizumab, when given in combination with carboplatin and pemetrexed compared to placebo. The administration of carboplatin and pemetrexed is a standard treatment for patients with non-squamous non-small cell lung cancer.
Key facts
- Study ID
- NCT02259582
- Run by
- OncoMed Pharmaceuticals, Inc.
- People needed
- 82
- Starts
- 2015-02-01
- Expected to finish
- 2017-04-07
- Last updated by the study team
- 2020-09-09
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Desert Hematology Oncology Medical Group, Inc. — Rancho Mirage, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Smilow Cancer Hospital at Yale-New Haven — New Haven, Connecticut, United States
- Ocala Oncology Center — Ocala, Florida, United States
- Edward H. Kaplan MD & Associates — Skokie, Illinois, United States
- Anne Arundel Medical Center — Annapolis, Maryland, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Broome Oncology, LLC — Binghamton, New York, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Hematology Oncology Associates of Rockland — Nyack, New York, United States
- Gaston Hematology & Oncology — Gastonia, North Carolina, United States
- Gabrail Cancer Center Research — Canton, Ohio, United States
- University Hospitals of Cleveland — Cleveland, Ohio, United States
- Texas Oncology-Baylor Charles A. Sammons Cancer Center — Dallas, Texas, United States
- University of Texas Medical Branch at Galveston — Galveston, Texas, United States
- Texas Oncology-Sherman — Sherman, Texas, United States
- Compass Oncology — Vancouver, Washington, United States
- Chris O'Brien Lifehouse — Camperdown, New South Wales, Australia
- The Kinghorn Cancer Centre — Darlinghurst, New South Wales, Australia
- North Coast Cancer Institute Port Macquarie Base Hospital — Port Macquarie, New South Wales, Australia
- Royall Brisbane & Women's Hospital — Herston, Queensland, Australia
- Icon Cancer Foundation — Milton, Queensland, Australia
- The Queen Elizabeth Hospital — Woodville South, South Australia, Australia
- Monash Health, Monash Cancer Centre-Moorabbin — Bentleigh East, Victoria, Australia
Full record on ClinicalTrials.gov
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