Evaluating Anodal tDCS Preceding Aphasia Therapy
Stopped early · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Stroke, Aphasia
In brief
The purpose of this study is to determine if non-invasive brain stimulation (transcranial direct current stimulation) delivered prior to language therapy will improve word-finding in individuals with aphasia who are 6 months or greater post-stroke.
Key facts
- Study ID
- NCT02249819
- Run by
- Northwell Health
- People needed
- 15
- Starts
- 2014-09-01
- Expected to finish
- 2017-11-01
- Last updated by the study team
- 2021-04-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥ 18 years of age
- First single focal unilateral left hemisphere lesion with diagnosis verified by brain imaging (MRI or CT scans) that occurred at least 6 months prior
- Pre-morbidly right handed
- Pre-morbidly fluent English speaker
- Cognitive function sufficient to understand the experiments and follow instructions (per interview with Speech Pathologist)
- A baseline Aphasia Quotient score between 10 to 94 out of 100 points on the Western Aphasia Battery (neither completely without language comprehension/expression nor fully recovered from aphasia).
You may not qualify if…
- Ongoing use of CNS-active medications
- Ongoing use of psychoactive medications, such as stimulants, antidepressants, and anti-psychotic medications
- Presence of additional potential tDCS risk factors:
- Damaged skin at the site of stimulation (i.e., skin with ingrown hairs, acne, razor nicks, wounds that have not healed, recent scar tissue, broken skin, etc.)
- Presence of an electrically, magnetically or mechanically activated implant (including cardiac pacemaker), an intracerebral vascular clip, or any other electrically sensitive support system
- Metal in any part of the body, including metal injury to the eye (jewelry must be removed during stimulation)
- A history of medication-resistant epilepsy in the family
- Past history of seizures or unexplained spells of loss of consciousness during the previous 36 months
- Pregnancy in women, as determined by self-report
Where it is running
- Feinstein Institute for Medical Research — Manhasset, New York, United States
Full record on ClinicalTrials.gov
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