Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants

Completed · Not applicable

Conditions studied: Respiratory Distress Syndrome, Bronchopulmonary Dysplasia

In brief

The primary aim of this study is to quantify and compare changes in lung volumes (as measured by functional residual capacity) in premature infants stable on continuous positive airway pressure (CPAP), and then randomized to two additional weeks of CPAP and room air versus room air alone. We hypothesize that infants randomized to additional CPAP will demonstrate an increased functional residual capacity (at the end of the two week study period and prior to discharge) compared to those randomized to room air.

Key facts

Study ID

NCT02249143

Run by

Oregon Health and Science University

People needed

50

Starts

2014-09-01

Expected to finish

2017-09-01

Last updated by the study team

2019-08-29

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Gestational age at birth <33 weeks
• Required CPAP for a minimum of 24 hours for respiratory distress
• Patient on CPAP and room air at time of randomization

You may not qualify if…

• Complex congenital heart disease other than patent ductus arteriosus or atrial septal defect
• Major malformations or chromosomal anomalies
• Multiple gestation greater than twins
• Culture proven sepsis or unstable at time of randomization

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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