Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study

Completed · Phase 1

Conditions studied: Mechanical Ventilation Complication

In brief

Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation. These drugs significantly cause tolerance and dependence, depresses the drive to breathe, and thus prolongs the need for mechanical ventilation and the associated complications. We propose IV CLON could be used as effectively as DEX.

Key facts

Study ID

NCT02249039

Run by

Johns Hopkins University

People needed

14

Starts

2015-09-01

Expected to finish

2019-12-01

Last updated by the study team

2021-03-01

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants and children age: 0-12 months
• Intubated and mechanically ventilated in the JHH PICU
• Meet criteria for starting dexmedetomidine (per PICU protocol)

You may not qualify if…

• Postoperative from complex congenital heart disease
• Asphyxia
• Traumatic Brain Injury
• Major Chromosomal anomaly (Trisomy 13, 18)
• Any infant or child who is receiving ECMO therapy
• If death is considered imminent

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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