Treatment of Muscle Weakness in Critically Ill Patients

Stopped early · Not applicable · Has a placebo group

Conditions studied: Critical Illness, Respiratory Failure, Myopathy, Weakness

In brief

Patients who are admitted to the intensive care unit and require mechanical ventilation frequently develop profound respiratory and limb muscle weakness. Studies show that the development of weakness during the ICU stay results in poor outcomes. Currently there are no treatments for this muscle weakness, but it has been suggested that this weakness might improve with physical therapy. Electrical stimulation is a method to provide direct stimulation to the muscles potentially enhancing function and improving strength. The purpose of this study is to test the hypothesis that neuromuscular electrical stimulation of the quadriceps muscle will improve muscle strength in patients who are critically ill on mechanical ventilation.

Key facts

Study ID

NCT02247895

Run by

Gerald Supinski

People needed

2

Starts

2016-12-01

Expected to finish

2018-02-01

Last updated by the study team

2020-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute respiratory failure requiring mechanical ventilation

You may not qualify if…

• Attending physician on service determines that patient too unstable to tolerate measurements
• Patient requires > 15mcg/min norepinephrine or > 15mg/kg/min of dopamine.
• Fraction of inspired oxygen > 80% or positive end expiratory pressure > 15 cm H20 requirements.
• Cardiac pacemaker or implanted defibrillator.
• Neuromuscular blocking agents delivered within 48 hours of preceding testing.
• Existing neuromuscular disease.
• Profound uncorrectable hypokalemia (< 2.5) OR hypophosphatemia (< 1.0)
• Acute lower extremity deep vein thrombosis
• Pregnancy
• Prisoner
• Institutionalized patient
• If primary attending determines that patient is terminal and will likely have care withdrawn within 7 days
• Do not resuscitate order
• Body mass index > 40
• Patients requiring mechanical ventilation more than 4 days prior to study entry

Where it is running

• University of Kentucky Medical Center — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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