Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer

Completed

Conditions studied: Triple Negative Breast Cancer

In brief

This study will determine if patient-derived tumor xenograft (PDX) mouse models can serve as a reliable model for treatment response for individual patients with triple negative breast cancer. The collection of patient tumor tissue will also provide insight into the mechanisms of therapeutic resistance for those individuals. Ultimately, this study will enhance our understanding of the genomic basis for treatment response for triple negative cancer on an individual basis, while having the potential to suggest new therapeutic options for high-risk triple negative breast cancer patients with residual disease post neoadjuvant.

Key facts

Study ID

NCT02247037

Run by

Icahn School of Medicine at Mount Sinai

People needed

68

Starts

2014-07-01

Expected to finish

2019-01-22

Last updated by the study team

2020-07-07

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• a histological diagnosis of invasive triple negative breast cancer determined by standard immunohistochemical analysis.
• must be candidates for neoadjuvant chemotherapy according to standard of care guidelines or have evidence of metastatic disease.
• must agree to a biopsy for research purposes at time of diagnosis and to undergo surgery at the hospitals of the Mount Sinai Health System.
• Patients with the following MAY be eligible:
• a histological diagnosis of ER and/or PR positive breast cancer with an overall receptor expression ≤ 30% breast cancer determined by standard immunohistochemical analysis

You may not qualify if…

• concurrent disease or condition that would make the patient inappropriate for study participation,
• any serious medical or psychiatric disorder that would interfere with the subject's safety, or inability to provide informed consent.
• vulnerable populations will not be included.

Where it is running

• Dubin Breast Center of The Tisch Cancer Institute at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

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