Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA

Completed · Not applicable

Conditions studied: Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome

In brief

The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S. population.The investigators propose to conduct this study that aims: (1) to compare right and left ventricular hemodynamic parameters using cardiac magnetic resonance imaging (MRI) in overlap syndrome vs. COPD only and OSA only; (2) to compare the effects of bi-level positive airway pressure (BPAP) vs. nocturnal oxygen therapy (NOT) on right ventricular (RV) hemodynamics in overlap syndrome. This study will allow us to test the hypothesis: (1) Patients with overlap syndrome have more RV dysfunction than those with COPD only or OSA only; (2) treatment of both hypoxemia and hypercapnia during sleep will improve RV hemodynamics compared with treatment of hypoxemia alone in patients with overlap syndrome.

Key facts

Study ID

NCT02244957

Run by

University of California, San Diego

People needed

23

Starts

2014-09-01

Expected to finish

2020-02-01

Last updated by the study team

2020-07-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Both men and women with age more than 18 years.
• Known diagnosis of stable COPD (GOLD stage 2 or higher) or OSA.

You may not qualify if…

• Already using continuous positive airway pressure (CPAP), BPAP device, or nocturnal oxygen.
• Known or suspected renal failure with estimated Glomerular filtration (GFR) <50 ml/min/1.73 m2 or serum creatinine > 1.5 mg/dl.
• Chronic atrial fibrillation or frequent premature ventricular contraction (> 10 beats per hour)
• Women known to be pregnant or planning to be pregnant in next 6 months.
• Known contraindication to MRI: cardiac pacemaker, metallic heart valves, metallic implants, history of claustrophobia.
• If taking sildenafil or related drugs, unable to stop it within 48 hours of the study visit.
• Uncontrolled COPD or acute COPD exacerbation.
• Unstable cardiac diseases.
• Known chronic inflammatory diseases like lupus or active infection.

Where it is running

• University of California, San Diego — San Diego, California, United States

Full record on ClinicalTrials.gov

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