Effects of Co-administration of Canagliflozin 300 mg and Phentermine 15 mg With Placebo in the Treatment of Non-Diabetic Overweight and Obese Participants

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity

In brief

The purpose of this study is to compare the effects of canagliflozin and phentermine to those of placebo to promote on a change in body weight over a 26 week period.

Key facts

Study ID

NCT02243202

Run by

Janssen Research & Development, LLC

People needed

335

Starts

2014-09-01

Expected to finish

2015-06-01

Last updated by the study team

2016-10-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must have BMI >=30 kg/m2 and <50 kg/m2 at screening or BMI >=27 kg/m2 and <50 kg/m2 at screening in the presence of a comorbidity of hypertension and/or dyslipidemia
• Must have stable weight, ie, change of < =5% in the 3 months before screening
• Must agree to utilize a highly effective method of birth control

You may not qualify if…

• An established diagnosis of diabetes mellitus
• Has a history of obesity with a known secondary cause (eg, Cushing's disease/syndrome)
• Has a history of hereditary glucose-galactose malabsorption or primary renal glycosuria
• Myocardial infarction, unstable angina, revascularization procedure, or cerebrovascular accident within 12 weeks before screening
• Has an Glycated hemoglobin (HBA1c) greater than or equal (>=) to 65 percent
• An average of 3 seated blood pressure (BP) readings of systolic BP >= 160 mm Hg and/or Diastolic BP >= 100 millimeters of mercury at screening

Where it is running

• Study site — Phoenix, Arizona, United States
• Study site — Walnut Creek, California, United States
• Study site — Jacksonville, Florida, United States
• Study site — Meridian, Idaho, United States
• Study site — Evansville, Indiana, United States
• Study site — Lexington, Kentucky, United States
• Study site — Louisville, Kentucky, United States
• Study site — New Orleans, Louisiana, United States
• Study site — Milford, Massachusetts, United States
• Study site — Manlius, New York, United States
• Study site — Warwick, Rhode Island, United States
• Study site — Mt. Pleasant, South Carolina, United States
• Study site — Nashville, Tennessee, United States
• Study site — Dallas, Texas, United States
• Study site — Odessa, Texas, United States
• Study site — Norfolk, Virginia, United States
• Study site — Wauwatosa, Wisconsin, United States

Full record on ClinicalTrials.gov

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