EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

Completed

Conditions studied: Acute Hepatic Porphyria

In brief

The purpose of this study is to characterize the natural history and clinical management of Acute Hepatic Porphyria (AHP) patients with recurring attacks.

Key facts

Study ID

NCT02240784

Run by

Alnylam Pharmaceuticals

People needed

136

Starts

2014-08-01

Expected to finish

2021-04-26

Last updated by the study team

2021-05-17

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females aged >/= 12 years
• Diagnosis of AHP [acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP) and aminolevulinic acid dehydratase (ALAD) deficient porphyria (ADP)]
• Porphyria attacks in the past 12 months or receiving treatment to prevent attacks
• Willing to provide written informed consent, medical records, and to comply with study requirements

You may not qualify if…

• Current participation in a clinical trial of an investigational product

Where it is running

• Clinical Trial Site — San Francisco, California, United States
• Clinical Trial Site — Miami, Florida, United States
• Clinical Trial Site — Ann Arbor, Michigan, United States
• Clinical Trial Site — New York, New York, United States
• Clinical Trial Site — Winston-Salem, North Carolina, United States
• Clinical Trial Site — Philadelphia, Pennsylvania, United States
• Clinical Trial Site — Galveston, Texas, United States
• Clinical Trial Site — Salt Lake City, Utah, United States
• Clinical Trial Site — Camperdown, New South Wales, Australia
• Clinical Trial Site — Leuven, Belgium
• Clinical Trial Site — Sofia, Bulgaria
• Clinical Trial Site — Prague, Czechia
• Clinical Trial Site — Helsinki, Finland
• Clinical Trial Site — Paris, France
• Clinical Trial Site — Chemnitz, Germany
• Clinical Trial Site — Petah Tikva, Israel
• Clinical Trial Site — Milan, Italy
• Clinical Trial Site — Modena, Italy
• Clinical Trial Site — Mexico City, Mexico
• Clinical Trial Site — Rotterdam, Netherlands
• Clinical Trial Site — Bergen, Norway
• Clinical Trial Site — Warsaw, Poland
• Clinical Trial Site — Cape Town, South Africa
• Clinical Trial Site — Seoul, South Korea
• Clinical Trial Site — Barcelona, Spain

Full record on ClinicalTrials.gov

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