Topiramate-Phentermine Combinations for Cocaine Dependence

Completed · Phase 1 · Has a placebo group

Conditions studied: Cocaine Use Disorder

In brief

This study will determine the influence of topiramate (Topamax®) and phentermine (Adipex®), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.

Key facts

Study ID

NCT02239913

Run by

University of Kentucky

People needed

38

Starts

2014-09-01

Expected to finish

2019-09-01

Last updated by the study team

2019-11-27

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Recent cocaine use by the intranasal or intravenous route

You may not qualify if…

• Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant
• Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion
• History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation
• Females not currently using effective birth control
• Contraindications to cocaine, topiramate or phentermine

Where it is running

• University of Kentucky Medical Center — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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