Screening Patients With Sickle Cell Disease for Kidney Damage

Completed

Conditions studied: Sickle Cell Disease

In brief

This study aims to study the temporal course of sickle nephropathy and assess novel biomarkers that can predict patients prone to nephropathy.

Key facts

Study ID

NCT02239016

Run by

Children's Hospital Medical Center, Cincinnati

People needed

320

Starts

2009-04-01

Expected to finish

2020-07-29

Last updated by the study team

2021-03-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Sickle cell disease (i.e. Hgb SS, Hgb SC, Sβ-Thalassemia)
• Individuals at baseline/steady state (absence of fever or acute sickle event, defined as vaso-occlusive pain crises, acute chest syndrome, splenic sequestration, stroke, priapism) for three weeks.
• Adult Subjects > 18 years of age: ability to consent to donate blood and/or urine for research purposes only.
• Newborn to < 18 years of age: ability of parent/legal guardian to consent for peripheral blood and/or urine samples to be obtained for research purposes only.

You may not qualify if…

• Hematologic malignancy
• Patients that either do not have the ability to undergo the informed consent process or whose parent/legal guardian does not have the ability to undergo the informed consent process

Where it is running

• Emory University (Children's Healthcare of Atlanta Pediatric Hospital) — Atlanta, Georgia, United States
• Univeristy of Louisville (Kosair Children's Hospital) — Louisville, Kentucky, United States
• National Institutes of Health Clinical Center — Bethesda, Maryland, United States
• Akron Childen's Hospital — Akron, Ohio, United States

Full record on ClinicalTrials.gov

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