Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes
Completed
Conditions studied: Chronic Obstructive Pulmonary Disease, HIV, Emphysema
In brief
The overall hypotheses of this proposal are that discrete phenotypes of HIV Chronic Obstructive Pulmonary disease (COPD) differ in their trajectories, biomarkers, and risk factors and that persistent viral infection including residual HIV is linked to HIV COPD.
Key facts
- Study ID
- NCT02238327
- Run by
- University of Pittsburgh
- People needed
- 232
- Starts
- 2014-09-01
- Expected to finish
- 2020-03-02
- Last updated by the study team
- 2020-10-08
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- HIV-1 infection, documented in medical record at any time prior to study entry.
- Men and women age 18 to 80.
- Ability and willingness to complete all tests.
- Participant in HLRC studies, MACS, Women's Interagency Health Study, and local HIV clinics.
- For UCSF only, new ART initiators from Women's Interagency Health Study or the HIV clinic
You may not qualify if…
- Pregnancy or breast-feeding.
- Contraindication to pulmonary function testing (i.e. abdominal or cataract surgery within 3 months, recent myocardial infarction, etc.).
- Increasing respiratory symptoms or febrile (temperature >100.40F [380C]) within 4 weeks of study entry.
- Hospitalization within 4 weeks prior to study entry (excluding mental health).
- Uncontrolled hypertension at screening visit (systolic > 180 mm Hg or diastolic > 100 mm Hg) from an average of two or more readings. Subject may return for screening after blood pressure is controlled.
- Active cancer requiring systemic chemotherapy or radiation.
- Active infection of lungs, brain, or abdomen.
- Intravenous drug use or alcohol use that will impair ability to complete study investigations in the opinion of the investigator
Where it is running
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.