Mask Ventilation Before and After Neuromuscular Blockade

Completed · Phase 4

Conditions studied: Anesthesia

In brief

Anesthesia providers are taught to "test" that they can properly ventilate a patient's lungs before administering a neuromuscular blocking drug (NMBD), rendering the patient apneic. This is a traditional teaching, not based on empirical evidence. The investigators primary hypothesis is that ventilation after the administration of NMBDs is non-inferior with that before their administration with respect to the composite safety endpoint of inadequate (MVi) and dead-space only (Vds) ventilation.

Key facts

Study ID

NCT02237443

Run by

University of Washington

People needed

210

Starts

2014-08-01

Expected to finish

2015-02-01

Last updated by the study team

2015-04-09

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who are 18 years or greater
• Present for elective surgery and
• Require placement of a breathing tube for their surgery

You may not qualify if…

• Patients will not be eligible if they are pregnant
• Are a minor
• Are a prisoner
• Have impaired decision-making capacity
• Have symptomatic untreated reflux
• Prior esophagectomy or hiatal hernia
• Vomiting within 24 hours of surgery
• Known oral or facial pathology making a proper mask fit unlikely
• Any condition for which the primary anesthesia team deems a rapid-sequence intubation to be appropriate
• Prior allergy or contraindication to receiving rocuronium, vecuronium, or succinylcholine.

Where it is running

• Harborview Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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