Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed

Stopped early · Not applicable

Conditions studied: Upper Gastrointestinal Bleed

In brief

Despite recommendations from clinical practice guidelines to discharge patients from the hospital on once daily proton pump inhibitors after acute management of UGIB, clinical practice is to use twice daily proton pump inhibitor therapy. The objective of this study will be to assess whether or not once daily pantoprazole is non-inferior to twice daily pantoprazole in ulcer healing with a dose of once daily versus twice daily proton-pump inhibitor following an upper gastrointestinal bleed. Additionally, this study will observe for any potential difference in safety for once daily versus twice daily proton pump inhibitors.

Key facts

Study ID

NCT02235311

Run by

University of Missouri-Columbia

People needed

3

Starts

2014-10-01

Expected to finish

2015-08-17

Last updated by the study team

2017-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult, 18 years and older; Upper GI bleed confirmed by endoscopy

You may not qualify if…

• Intensive Care Unit admission, Emergency endoscopic intervention required to control bleeding, Malignant appearing ulcers as determined by endoscopy, Previous documented treatment with twice daily PPI for other indication, Receiving twice daily PPI therapy prior to admission

Where it is running

• University Hospital — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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