Selonsertib in Adults With Pulmonary Arterial Hypertension
Completed · Phase 2 · Has a placebo group
Conditions studied: Pulmonary Arterial Hypertension
In brief
The primary objective of this study is to evaluate the effect of selonsertib (GS-4997) on pulmonary vascular resistance (PVR), as measured by right heart catheterization (RHC) in adults with pulmonary arterial hypertension (PAH). The study will consist of a 24-week placebo-controlled treatment period and a long-term selonsertib treatment period. Participants completing the 24-week placebo-controlled period will be eligible to receive active treatment with selonsertib in the long-term treatment period.
Key facts
- Study ID
- NCT02234141
- Run by
- Gilead Sciences
- People needed
- 151
- Starts
- 2014-11-01
- Expected to finish
- 2016-12-01
- Last updated by the study team
- 2019-04-10
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of South Alabama Medical Center — Mobile, Alabama, United States
- Advanced Lung Disease Institute — Phoenix, Arizona, United States
- Arizona Pulmonary Specialist, Ltd — Phoenix, Arizona, United States
- University of Arizona Clinical and Translational Science (CATS) Research Center — Tucson, Arizona, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, California, United States
- University of California, Davis — Sacramento, California, United States
- University of California, San Francisco — San Francisco, California, United States
- LA Biomedical Research Institute Harbor-UCLA Medical Center — Torrance, California, United States
- University of Colorado Cardiac and Vascular Center, Anschutz Inpatient Pavillion — Aurora, Colorado, United States
- The Emory Clinic — Atlanta, Georgia, United States
- University of Chicago Medicine — Chicago, Illinois, United States
- Boston University Medical Center — Boston, Massachusetts, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- University of Michigan Health System — Ann Arbor, Michigan, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Mary M. Parkes Center // University of Rochester Medical Center — Rochester, New York, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- Martha Morehouse Medical Pavilion — Columbus, Ohio, United States
- Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
- UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania, United States
- UT Southwestern Medical Center — Dallas, Texas, United States
- Inova Fairfax Medical Campus — Falls Church, Virginia, United States
- Peter Lougheed Center — Calgary, Alberta, Canada
Full record on ClinicalTrials.gov
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