Phendimetrazine and Cocaine

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Cocaine Use Disorder

In brief

This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will be conducted in which the subjective and physiological effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.

Key facts

Study ID

NCT02233647

Run by

William Stoops

People needed

11

Starts

2014-09-01

Expected to finish

2015-12-01

Last updated by the study team

2017-09-27

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Recent cocaine use

You may not qualify if…

• Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant
• Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion
• History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation
• Females not currently using effective birth control
• Contraindications to cocaine or phendimetrazine

Where it is running

• University of Kentucky Laboratory of Human Behavioral Pharmacology — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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