BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis

Completed · Phase 2 · Has a placebo group

Conditions studied: Osteoarthritis

In brief

This study will evaluate the efficacy and safety of a single intra-articular injection of 2 doses of BOTOX® (onabotulinumtoxinA) compared with placebo as treatment for knee osteoarthritis symptoms.

Key facts

Study ID

NCT02230956

Run by

Allergan

People needed

176

Starts

2014-10-01

Expected to finish

2016-03-01

Last updated by the study team

2017-05-31

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Painful osteoarthritis
• Able to discontinue anti-inflammatory drugs and analgesics
• Must be ambulatory without assistive walking devices

You may not qualify if…

• Chronic pain conditions other than knee osteoarthritis
• Treatment with corticosteroids in the study knee within 12 weeks
• Treatment with hyaluronic acid in the study knee within 24 weeks
• Previous treatment with any botulinum toxin for any reason
• Diagnosis of myasthenia gravis, Eaton-Lambert syndrome, or amyotrophic lateral sclerosis

Where it is running

• Study site — Artesia, California, United States
• Study site — Pardubice, Czechia
• Study site — Vejle, Denmark

Full record on ClinicalTrials.gov

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