Endothelial Microparticles: A Novel Marker of Vascular Dysfunction

Completed

Conditions studied: Chronic Kidney Disease

In brief

The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment with calcineurin inhibitors (CNIs) are each associated with the release of endothelial microparticles into the plasma.

Key facts

Study ID

NCT02230202

Run by

University of Colorado, Denver

People needed

90

Starts

2014-09-01

Expected to finish

2016-03-01

Last updated by the study team

2018-02-28

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For Healthy controls:
• BMI less than 40 kg/m\^2
• Able to give informed consent
• For Stage III or IV CKD patients:
• BMI less than 40 kg/m\^2
• Able to give informed consent
• An estimated Glomerular-Filtration Rate (GFR) of 20-60 mL/min/1.73m\^2
• For Post-kidney transplant and stage III or IV CKD patients:
• BMI less than 40 kg/m\^2
• Able to give informed consent
• An estimated Glomerular-Filtration Rate (GFR) of 20-60 mL/min/1.73m\^2

You may not qualify if…

• For Healthy controls:
• Women pregnant or breastfeeding
• For Stage III or IV CKD patients:
• Women pregnant or breastfeeding
• Adults with a life expectancy of less than one year
• A history of significant liver disease or congestive heart failure
• Hospitalization within the last three months
• Active infection on antibiotic therapy
• Uncontrolled hypertension (>140/90)
• Immunosuppressive therapy within the last year
• For Post-transplant stage III or IV CKD patients:
• Women pregnant or breastfeeding
• Adults with a life expectancy of less than one year
• A history of significant liver disease or congestive heart failure
• Hospitalization within the last three months
• Active infection on antibiotic therapy
• Uncontrolled hypertension (>140/90)

Where it is running

• University of Colorado Anschutz Medical Campus; CTRC — Aurora, Colorado, United States
• University of Colorado School of Medicine — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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