Magnetic Resonance Elastography in Hydrocephalus

Running, not enrolling · Not applicable

Conditions studied: Hydrocephalus

In brief

The purpose of this project is to assess the utility of a new magnetic resonance technique called magnetic resonance elastography (MRE) in the non-invasive diagnosis of normal pressure hydrocephalus. The investigators hypothesize that MRE produces a unique imaging signature for hydrocephalus that distinguishes the disease from the normal (non-hydrocephalic) but atrophied brain, a distinction not possible with conventional MR imaging studies that are presently available.

Key facts

Study ID

NCT02230124

Run by

Dartmouth-Hitchcock Medical Center

People needed

35

Starts

2007-03-01

Expected to finish

2028-12-30

Last updated by the study team

2026-07-22

Who can join

Age: 45 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age >21;
• One or more of the following complaints: memory loss/dementia, urinary incontinence, or progressive gait disturbance
• Ventriculomegaly defined as temporal horn width >2 mm or a FH:ID ratio>30% on computed tomography or MRI, where FH is the maximal distance between the frontal horns and ID is the internal diameter from inner table to inner table of the skull at this level (Greenberg)
• A diagnosis of any adult onset hydrocephalus (NPH, post-traumatic, post-hemorrhagic, obstructive, or idiopathic) will be considered for enrollment in this study

You may not qualify if…

• Implanted neuro-stimulator or cardiac pacemaker
• Known coagulopathy; major organ dysfunction
• End-stage congestive heart failure
• Oxygen-dependent pulmonary disease, hepatic cirrhosis, or dialysis- dependent renal failure; or other condition which, according to the assessment of the treating surgeon or anesthesia team
• Precludes consideration of elective surgery
• Patients who may be pregnant will be excluded from this study as well

Where it is running

• Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States

Full record on ClinicalTrials.gov

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