Efficacy of High Flow Therapy in COPD At Home

Stopped early

Conditions studied: COPD

In brief

Preliminary data show that in COPD patients, HFT substantially decreases ventilatory demand during sleep. The central hypothesis of this proposal is that lowering ventilatory demand using nasal high-flow therapy during sleep will elevate lung function, reduce dyspnea on exertion and improve quality of life. Thus, this proposal aims will determine the effects HFT over time on 1) lung function; 2) dyspnea on exertion; and 3) quality of life.

Key facts

Study ID

NCT02230020

Run by

Johns Hopkins University

People needed

8

Starts

2013-08-15

Expected to finish

2015-12-13

Last updated by the study team

2017-08-08

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Consenting adults over the age of 18 with COPD

You may not qualify if…

• 1. Apnea Hypopnea Index>15 events/hr 2. Use of Non-invasive positive pressure ventilation (CPAP + Bilevel) 3. Severe bilateral nasal obstruction (apparent mouth breathing at rest) 4. Documented clinical cardiovascular disease, as defined below:
• myocardial infarction in past 3 months
• revascularization procedure in past 3 months
• implanted cardiac pacemaker or ICD
• unstable arrhythmias
• congestive heart failure with ejection fraction < 40%
• uncontrolled hypertension (BP > 190/110) 5. History of end stage renal disease (on dialysis) 6. History of end stage liver disease, such as:
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• Jaundice
• ascites
• history of recurrent gastrointestinal bleeding
• transjugular intrahepatic portosystemic shunt (TIPS) ; 7. Transportation industry worker (commercial truck or bus drivers, airline pilots) 8. Known pregnancy (by self report) 9. Known coagulopathy or anticoagulant use (e.g. coumadin) other than aspirin. 10. Do you take medications for any of the following reasons:
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• Pain control (besides NSAIDs)
• Sleep medication
• Benzodiazepines
• Methadone

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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