Molecular Mechanisms Underlying Prostate Cancer Disparities

Completed

Conditions studied: Prostate Cancer

In brief

The purpose of this study is to further elucidate the molecular mechanisms underlying prostate cancer disparities. In previous work the investigators have identified a set of differentially deregulated genes in African American versus Caucasian American prostate cancer. Based on these findings, they hypothesize that they will be able to validate these targets, originally identified in the previous work conducted at The George Washington University Medical Center, in an independent Duke University Medical Center cohort of prostate cancer specimens. In addition, the investigators hypothesize that they will be able to discover novel targets in the Duke University Medical Center cohort of prostate cancer specimens because of regional differences.

Key facts

Study ID

NCT02229565

Run by

Duke University

People needed

226

Starts

2014-11-01

Expected to finish

2019-10-14

Last updated by the study team

2020-11-13

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Suspected malignancy of prostate cancer
• Self-reported race of African American or Caucasian American
• Age >/= 18 years
• Able to read, understand and sign an informed consent document

You may not qualify if…

• Collected tumor tissue is inadequate for DNA and RNA analysis and/or is not positive for adenocarcinoma of the prostate.
• Patients with prior systemic therapy will not be eligible for the study, i.e. radiation or chemo or immunotherapy.

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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